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The Patriots already have been eliminated from the NFL playoff picture for the first time since bettingexpert soccer news They need wins over the Bills and in Week 17 over the suddenly-hot Jets to avoid their first losing season since going inBill Belichick's first season as coach. Kickoff is set for p. Buffalo is a 7. Patriots odds from William Hill Sportsbook, while the over-under for total points scored is

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Betting odds comparator mc

Methods Two hundred and fifty-eight persons took part in the study: Logistic regressions were carried out to assess the link between the accuracy of the forecasted scores and the expertise of the participants expert, amateur, layperson, controlling for age and gender. Conclusions Expertise, age, and gender did not appear to have an impact on the accuracy of the football match prognoses. Public health policies may need to consider the phenomenon in order to prevent problem gambling related to football betting.

Football soccer is one of the most popular sports in the world, including Europe. If unfounded, however, this belief should be considered as a form of "illusion of control. Two hundred and fifty-eight persons took part in the study: Logistic regressions were carried out to assess the link between the accuracy of the forecasted scores and the expertise of the participants expert, amateur, layperson , controlling for age and gender.

Expertise, age, and gender did not appear to have an impact on the accuracy of the football match prognoses. Therefore, the belief that football expertise improves betting skills is no more than a cognitive distortion called the "illusion of control. Scythopolis - Bet Shean-, city of the decapolis. Ergonomics SA. Journal Homepage Image. Ergonomics SA esa provides a medium for publication of material relevant to occupational conditions and needs in Southern Africa at a time of change unparalleled in history.

To this end the journal accepts articles in the following categories: research papers, review articles, conceptual theories, SA Rugby. SA Rugby Youth Week players: a pilot study. J Brown,1, Consensus Statement for Concussion in Sport [1] and World. Laukhina, E. Fiziki Tverdogo Tela; Laukhin, V. Here the synthesis, X-ray structure, and physical properties of two hydrated halides of BET -TTF that are isostructural and present stable metallic properties are described.

Given these characteristics, it is possible that profitable wagering strategies could exist for informed bettors of the WNBA. Using betting data on the WNBA from —, we find that simple betting strategies do not earn statistically significant returns. WNBA bettors are like NBA bettors; however, in that they strongly prefer the best teams, particularly when they are on the road.

Despite this clear bias, betting against the most popular public wagers is not found to earn statistically significant profits. The informational content of odds posted in sports betting market has been an ongoing topic of research. In this paper, I test whether fixed odds betting markets in soccer are informationally efficient. The contributions of the paper are threefold: first, I propose a simple yet flexible statistical. See www. On the effect of taxation in the online sports betting market.

We analyse the effect of taxation in the online sport betting market. This market is characterized by its negligible marginal costs. We model the two most popular online sport betting bets : fixed-odds and spread, as compared with another traditional sport betting : parimutuel. Rejection of attractive gambles is explained by loss aversion, while counterproductive risk seeking is attributed Introduction to the TD build project network.

TD build project network includes three layers. The second layer has m level and each level has horizontal subnetwork composed of n cluster bin NDn. The third layer is equipment. The number of the equipment of per cluster bin NDn is TD network is used for P project.

It has highest running reliability and long-term stability as well as powerful suitability and flexibility. It has many tie points, strong real-time ability and excellent interference suppression. Through testing, all kinds of characteristics are satisfactory. It is an ideal selection for industrial use. Asthma: T- bet — A Master Controller? Clinical trials for BET inhibitors run ahead of the science. Several cancer clinical trials for small molecule inhibitors of BET bromodomain proteins have been initiated.

There is enthusiasm for the anti-proliferative effect of inhibiting BRD4, one of the targets of these inhibitors, which is thought to cooperate with MYC, a long-desired target for cancer therapeutics. Each BET protein controls distinct transcriptional pathways that are important for functions beyond cancer cell proliferation, including insulin production, cytokine gene transcription, T cell differentiation, adipogenesis and most seriously, active repression of dangerous latent viruses like HIV.

Failure to appreciate that at concentrations used, no available BET inhibitor is member-selective, or to develop a sound biological basis to understand the diverse functions of BET proteins before undertaking for these clinical trials is reckless and likely to lead to adverse events. More mechanistic information from new basic science studies should enable proper focus on the most relevant cancers and define the expected side effect profiles. All rights reserved. Heuristic and analytic processing in online sports betting.

This article presents the results of two studies that examine the occurrence of heuristic i. The first study was qualitative and was conducted with a convenience sample of 12 regular online sports gamblers who described the processes by which they arrive at a sports betting decision.

The results of this study showed that betting online on sports events involves a mix of heuristic and analytic processes. The second study consisted in a survey of online sports gamblers where performance in terms of monetary gains, experience in online sports betting , propensity to collect and analyze relevant information prior to betting , and use of bookmaker odds were measured.

This study showed that heuristic and analytic processes act as mediators of the relationship between experience and performance. The findings stemming of these two studies give some insights into gamblers' modes of thinking and behaviors in an online sports betting context and show the value of the dual mediation process model for research that looks at gambling activities from a judgment and decision making perspective.

This paper collects the measurement results of MHZMHZ spectrum in the coastal areas, and analyzes the characteristics of TV broadcast spectrum occupancy in the measurement region. It is shown that the polinomial extrapolation of the wave function to the nonphysical region of the variable Q 2 turns not to be sure for determination of the coupling constants. The CUT- TD code has been developed to find minimal cut sets for a given fault tree and to calculate the occurrence probability of its top event.

This code uses an improved top-down algorithm which can enhance the efficiency in deriving minimal cut sets. As a result, this processing directly produces cut sets for the redefined single gate with each gate not being developed. This option can reduce the number of minimal cut sets, save the computing time and assists the user in reviewing the result. A content analysis of how 'normal' sports betting behaviour is represented in gambling advertising.

The pervasiveness of sports betting marketing and advertising is arguably normalising betting behaviour among increasingly larger groups of population. In their adverts, bookmakers represent characters and situations that conventionalise betting and promote specific behaviours while ignoring others.

Using content an Betting patterns for sports and races: a longitudinal analysis of online wagering in Australia. Online wagering is increasing in popularity as it is easily accessible through websites which market these services widely.

However, few studies have examined online betting based on actual behavioural data. This paper describes the results of an analysis of 2,, bets placed with an Australian online wagering operator over a 1-year period. The majority of bets placed were for a win Sports betting was dominated by ball sports, reflecting popular interest in these events. More than three-quarters The most popular bets placed to win, had a relatively high rate of losses and lowest average returns, which may reflect less sophisticated betting behaviour.

More specific handicap and total bets were placed by fewer customers, but were larger bets with the greatest returns. Similarly, bets placed on less popular sporting events had greater average returns potentially reflecting greater customer sophistication and knowledge raising the possibility of a proportion of bettors being more 'skilled'.

As the first paper to analyze the types of bets placed on events and outcomes the results support the notion that wagering is an entertainment activity, and the majority of customers are motivated by factors other than simply winning money. Extracting local information from crowds through betting markets.

In this research, a set-up is considered in which users can bet against a forecasting agency to challenge their probabilistic forecasts. From an information theory standpoint, a reward structure is considered that either provides the forecasting agency with better information, paying the successful providers of information for their winning bets , or funds excellent forecasting agencies through users that think they know better.

Especially for local forecasts, the approach may help to diagnose model biases and to identify local predictive information that can be incorporated in the models. The challenges and opportunities for implementing such a system in practice are also discussed. Becker's side bet theory remaining in a job because of perceived costs of leaving was tested using data from working business students.

Three factors were most consistent with the theory: bureaucratic organization, nonwork-related concerns, and adjustment to social position. Attachment to the organization was significantly linked to tangible…. The double french nuclear bet was an ultimate political choice of an old nation which did not wanted to renounce its glamour.

Is it always possible to conceive a national energy policy, knowing that the french military nuclear strategy is opposed to the rules of the next International Penal Court? Delayed bet -hedging resilience strategies under environmental fluctuations. Many biological populations, such as bacterial colonies, have developed through evolution a protection mechanism, called bet hedging, to increase their probability of survival under stressful environmental fluctuation.

In this context, the concept of preadaptation refers to a common type of bet -hedging protection strategy in which a relatively small number of individuals in a population stochastically switch their phenotypes to a dormant metabolic state in which they increase their probability of survival against potential environmental shocks. Hence, if an environmental shock took place at some point in time, preadapted organisms would be better adapted to survive and proliferate once the shock is over.

In many biological populations, the mechanisms of preadaptation and proliferation present delays whose influence in the fitness of the population are not well understood. In this paper, we propose a rigorous mathematical framework to analyze the role of delays in both preadaptation and proliferation mechanisms in the survival of biological populations, with an emphasis on bacterial colonies. Our theoretical framework allows us to analytically quantify the average growth rate of a bet -hedging bacterial colony with stochastically delayed reactions with arbitrary precision.

We verify the accuracy of the proposed method by numerical simulations and conclude that the growth rate of a bet -hedging population shows a nontrivial dependency on their preadaptation and proliferation delays. Contrary to the current belief, our results show that faster reactions do not, in general, increase the overall fitness of a biological population. Operationens fokus forud for de udenlandske troppers exit er at udvikle sikkerhedsinstitutionerne og skabe arbejdspladser Hjemmesiden giver overblik In total, 80 participators 15 students, 20 workers, 20 civil servants, 15 handicraftsmen and 10 self employments participated to study and filled in the questionnaire that expert opinion was taken, validity and reliability were done, According to the results acquired, it was determined that participators take part in betting to enhance the quality of life, bring enjoy and attraction of their life, getting rid of stress and most importantly making money because of some reasons such as economic crisis and financial difficulty in their society, their low income level and their debts.

MYC-amplified medulloblastomas are highly lethal tumors. Bromodomain and extraterminal BET bromodomain inhibition has recently been shown to suppress MYC-associated transcriptional activity in other cancers. We evaluated the effects of genetic and pharmacologic inhibition of BET bromodomains on proliferation, cell cycle, and apoptosis in established and newly generated patient- and genetically engineered mouse model GEMM -derived medulloblastoma cell lines and xenografts that harbored amplifications of MYC or MYCN.

We assessed the in vivo efficacy of JQ1 in orthotopic xenografts established in immunocompromised mice. Treatment of MYC-amplified medulloblastoma cells with JQ1 decreased cell viability associated with arrest at G1 and apoptosis. The exogenous expression of MYC from a retroviral promoter reduced the effect of JQ1 on cell viability, suggesting that attenuated levels of MYC contribute to the functional effects of JQ1. SFI attenuated lung injury and regulated lung immune disorders.

Betting on impulse, without thoughtful consideration, research or informed decision-making, may cause financial and other harms and lead to the development of gambling problems. Impulse betting undermines responsible consumption of gambling because it reflects self-regulatory failure, impaired control, unreflective decision-making and betting more than planned. In this paper we define impulse gambling and report on a study that aimed to understand more about the intrinsic characteristics of sports bettors who have a greater tendency to bet on impulse.

Specifically, the study aimed to identify behavioural, psychological and socio-demographic predictors of impulse sports betting. A sample of Australian sports bettors completed an online survey that measured the proportion of their bets placed on impulse both before and during sporting events, as well as bets that were researched and planned in advance.

Impulse betting was common, accounting for nearly one-half of all past-year sports bets by respondents. Over three-quarters of respondents had placed one or more impulse bets in the last year and one in seven respondents had made all of their sports bets on impulse. More impulsive sports bettors were characterised as having higher trait impulsiveness, higher problem gambling severity, more frequent sports betting and a shorter history of sports betting.

They favoured betting on in-match contingencies instead of overall match outcomes. While health promotion strategies are needed to discourage impulse betting , research into contextual factors that arouse urges to bet would also provide direction for harm minimisation measures that help consumers to resist impulsive betting decisions. Understanding persuasive attributes of sports betting advertisements: A conjoint analysis of selected elements. Background and aims Despite recent growth in sports betting advertising, minimal research has examined the influence of different advertising message attributes on betting attitudes and behaviors.

This study aimed to identify which attributes of sports betting advertisements most engage attention, interest, desire and likelihood of betting among non-problem, low-risk, moderate-risk, and problem gamblers. Methods A novel approach utilizing an experimental design incorporating conjoint analysis examined the effects of: three message formats commentary, on-screen display, and studio crossover ; four appeals neutral, jovial, ease of placing the bet , and sense of urgency ; three types of presenters match presenter, sports betting operator, and attractive non-expert female presenter ; and four bet types traditional, exotic key event, risk-free, and micro- bet.

A professional film company using paid actors produced 20 mock television advertisements simulating typical gambling messages based on the conjoint approach. These were embedded into an online survey of Australian adults. Results The most attention-grabbing attributes were type of presenter and type of bet. The attractive non-expert female presenter gained more attention from all gambler groups than other presenters. The type of bet was most persuasive in converting attention into likely betting among all gambler groups, with the risk-free bet being much more persuasive than other bet types.

Problem gamblers were distinct by their greater attraction to in-play micro- bets. Discussion and conclusion Given the potential for incentivized bets offering financial inducements and for in-play micro- bets to undermine harm minimization and consumer protection, regulators and wagering operators should reconsider whether these bet types are consistent with their responsible gambling objectives.

Manin has constructed quantum theta functions from the lattice embedding into vector space x finite group. We extend Manin's construction of quantum thetas to the case of general embedding of vector space x lattice x torus. It turns out that only for the vector space part of the embedding there exists the holomorphic theta vector, while for the lattice part there does not.

Furthermore, the so-c Internet-based structural characteristics of sports betting and problem gambling severity: is there a relationship? With the adoption and popularization of internet-based platforms, sports betting has introduced new functionalities that transform the design of its products and therefore the way bettors interact with them. This study aims to explore the association between the use of new structural characteristics of online betting and gambling severity.

Five characteristics are examined here: i live in-play betting ; ii cash out feature use as example of in-play betting in-built features ; iii fantas Archives: Water SA. Items 1 - 50 of Log in or Register to get access to full text downloads. Vol 44, No 1 Archives: Health SA Gesondheid. Items 1 - 42 of No risk, no fun-- betting on sports events costs the gamblers a lot of money and brings excellent profits to those who offer the bets.

Among the people who bet on a regular basis, the proportion of young adults is frighteningly high. We now suggest a concept as part of a basic mathematics course for acquiring the necessary mathematical knowledge…. A lot of people risk money with bets on sport events or other events. Bookkeepers that offer such bets earn a lot of money. We are making a proposal more exactly: a concept for a part of a basic mathematics course for learning mathematics behind the screen internet bets are very popular.

Learners should organize a "sports event"…. A strategic assessment of the sports betting industry in the United Kingdom. The dissertation focuses on the field of strategic management, through which it tries to identify the competitive advantage of three operators in the United Kingdom online sports betting market; Betfair Group plc, Bet and William Hill plc. Even in the case of hydrated particles, for which vertical excitations are generally well described with all XC potentials, the use of TD -B3LYP appears to result in CT-problems for certain particles.

Rejection of attractive gambles is explained by loss aversion, while counterproductive risk seeking is attributed to limited level of reasoning. The current research highlights a shortcoming of this popular but often implicit "contradicting biases" assertion.

Studies of "negative-sum betting games" reveal hig Full Text Available The present work has great importance for the economic and financial area due to the fact that targets the relevance of the financial indicators in anticipation of the stock variation. The aim is to measure the correlation, the type and intensity, between the variation of stock market profitability and the profitability of the securities traded by banks in Romania, listed on the BSE.

The research is approached transversely banks in Romania listed on the stock market as well as longitudinally from the date of listing on the Stock Exchange of each bank until Rovira, C. Khimicheskoj Fiziki; Doublet, M. The first example of a metallic charge-transfer salt derived from cis-bis ethylenethio -tetrathiafulvalene BET -TTF is reported. X-ray crystal structure of the mixed-valence salt revealed that trans-cis isomerization occurs upon one electron oxidation.

In spite of the structural disorder in both BET -TTF and the counterion, salt is metallic down to 60 K and then resistance increases slowly down to 4 K. When more than one TDD network operates in adjacent frequency bands, severe interference may happen due to adjacent channel interference ACI and unsynchronized operations.

In this paper, coexistence issues between TD -LTE and other systems are analyzed and coexistence requirements are provided. This paper has three research objectives. Second, an uplink scheduling algorithm is proposed to utilize a leakage pattern of ACI in synchronized operations.

Third, minimum requirements for coexistence in unsynchronized operations are analyzed by introducing a concept of adjacent-channel coupling loss. From the analysis and simulation results, we can see that coexistence of TD -LTE with other TDD systems is feasible if the two networks are synchronized. For the unsynchronized case, some special cell-site engineering techniques may be required to reduce the ACI.

SA Journal of Radiology. Health SA Gesondheid. Histone acetylation regulates activation and repression of multiple inflammatory genes known to play critical roles in chronic inflammatory diseases. However, proteins responsible for translating the histone acetylation code into an orchestrated pro-inflammatory cytokine response remain poorly characterized.

We hypothesize that members of the BET family of dual bromodomain-containing transcriptional regulators directly control inflammatory genes. We examined the genetic model of brd2 lo mice, a BET protein hypomorph, to show that Brd2 is essential for pro-inflammatory cytokine production in macrophages. Furthermore, we show that Brd2 and Brd4 physically associate with the promoters of inflammatory cytokine genes in macrophages.

We propose that targeting BET proteins with small molecule inhibitors will benefit hyper-inflammatory conditions associated with high levels of cytokine production. However, proteins responsible for translating the histone acetylation code into an orchestrated proinflammatory cytokine response remain poorly characterized. Bromodomain and extraterminal BET proteins are "readers" of histone acetylation marks, with demonstrated roles in gene transcription, but the ability of BET proteins to coordinate the response of inflammatory cytokine genes through translation of histone marks is unknown.

We examined the genetic model of brd2 lo mice, a BET protein hypomorph, to show that Brd2 is essential for proinflammatory cytokine production in macrophages. We propose that targeting BET proteins with small-molecule inhibitors will benefit hyperinflammatory conditions associated with high levels of cytokine production.

Comparison of TiC coating and TD coating in actual application. Amount of deformation was measured and compared to find the process which gives the least deformation. Wear tests were carried out for specimens treated by each process.

BET domain co-regulators in obesity, inflammation and cancer. Bromodomain proteins are chromatin 'readers'; they recruit chromatin-regulating enzymes, including 'writers' and 'erasers' of histone modification, to target promoters and to regulate gene expression. Conventional wisdom held that complexes involved in chromatin dynamics are not 'druggable' targets. However, small molecules that inhibit bromodomain and extraterminal BET proteins have been described.

We examine these developments and discuss the implications for small molecule epigenetic targeting of chromatin networks in cancer. BET bromo- domain inhibition gene expression response. Down-, up- and non The x-axis shows position along the chromosome with gene. Correlations between TD annihilation and oxygen precipitation in Czochralski-grown silicon. The investigations show that 1 TD 's cannot act as nuclei for oxide precipitates and that 2 their annihilation, connected with the increased formation of Si I induced defects RLD's , proves TD 's to consist also of self-interstitials.

Td T activity in acute myeloid leukemias defined by monoclonal antibodies. Blast cells from eight out of 71 patients diagnosed with acute myeloid leukemia AML by morphological, cytochemical, and immunological criteria showed Td T activity. Full text of publication follows. The main objective of the Action is to increase the knowledge of imaging-guided drug delivery procedures and to apply this knowledge to the development of theranostic agents through an interdisciplinary approach that involves chemists, biologists, imaging and pharmaceutical technologists.

Investigations devoted to the design, synthesis, physico-chemical characterization and testing of imaging reporters tailored for theranostic applications are carried out. Some results appear particularly worth to be noted: novel chelator system for Sc radionuclides and for MRI, macrocyclic ligands containing bis phosphonate side arm s yielding excellent systems for the coordination of Ga, applications of this and other PET isotopes e.

In the MRI field, where the sensitivity is the key-issue, it has been shown that innovative systems, based on Gd, may allow the in vivo visualization of cellular targeting and may serve as multimodal probes. The results from the research activities carried out in the. The ultraviolet galactic background from TD -1 satellite observations. Using statistical tests those data contaminated by noise due to charged particles in the atmosphere have been discarded, and the remainder have been arranged to form ultraviolet profiles of the Galaxy.

These profiles have been constructed at and A. The zodiacal light components of the total radiation field have been separated from the galactic components to give the intensity of the zodiacal light at elongation 90 0 as function of ecliptic latitude.

The spectrum of the zodiacal light in the near ultraviolet is found to be redder than that of the Sun. The intensity of the diffuse galactic light as a function of galactic latitude has been obtained by subtraction of the zodiacal light and contributions due to faint stars calculated using an axi-symmetric model of the Galaxy. On comparison with predictions of the diffuse galactic light from a radiative transfer model it is found that the ratio of the albedos at and A is relatively insensitive to the model used, and is 0.

The albedo at A is found to be 0. Lee is still very active at over 80, pursuing his theory work to this day. Lisa Randall's two initial papers have been quoted both more than times, making her the most cited theoretical physicist in the world in the last five years as of last autumn - a total of about 10, citations!

A mathematical analysis of an exchange-traded horse race betting fund with deterministic payoff betting strategy for institutional investment to challenge EMH. The primary hypothesis challenges the semi-strong efficient market hypothesis applied to horse race wagering.

An optimal deterministic betting model DBM is derived from the existing stochastic model fundamentals, mathematical pooling principles, and new theorem. The exchange-traded betting fund ETBF is derived from force of interest first principles. Alpha is excess return above financial benchmark, and invokes betting strategy alpha that is composed of model alpha and fund alpha. The results and analysis from statistical testing of a global stratified data sample of three hundred galloper horse races accepted at the ninety-five percent confidence-level positive betting strategy alpha, to endorse an exchange-traded horse race betting fund with deterministic payoff into financial market.

Does the uptake of wagering inducements predict impulse betting on sport? Background and aims Marketing inducements for addictive products, such as wagering, can prompt impulse purchasing by triggering consumption reminders, urges, and cravings.

Wagering inducements incentivize betting by providing bonus bets , money-back guarantees, deposits into betting accounts, and discounts. Their promotion during sporting events, push marketing efforts directed at consumers, and ease of uptake at the point-of-sale, may trigger betting on impulse.

This study examined whether the uptake of wagering inducements predicted impulse betting on sport. Results More frequent users of wagering inducements had a greater tendency to place impulse in-play bets , which were also predicted by problem gambling, higher buying impulsiveness, higher frequency of watching sports, younger age, and higher educational status. Sports bettors with a greater tendency to place impulse bets before match commencement also tended to have higher buying impulsiveness and to be younger, but they used inducements less frequently, and tended to be female, less-educated and non-problem, moderate risk, or problem gamblers.

Discussion and conclusions Uptake of wagering inducements appeared to be particularly effective in stimulating impulse in-play betting among problem gamblers and frequent sports viewers. These results suggest that a more cautious approach to the regulation of both in-play bets and wagering inducements may be required to better protect young adults from gambling problems and harm. Strain TD 1 was Gram positive, rod-shaped, aerobic, motile, and endospore forming.

The cell was 2. The cellular fatty acid content was mainly C, which comprised Bayesian tree analysis strongly supported the idea that strain TD 1 is affiliated with genus Aeribacillus, as Aeribacillus pallidus strain TD 1. The cellular fatty acid content was mainly C , which comprised A number of diazepines are known to inhibit bromo- and extra-terminal domain BET proteins.

Their BET inhibitory activity derives from the fusion of an acetyl-lysine mimetic heterocycle onto the diazepine framework. Herein we describe a straightforward, modular synthesis of novel 1,2,3-triazolobenzodiazepines and show that the 1,2,3-triazole acts as an effective acetyl-lysine mimetic heterocycle. Structure-based optimization of this series of compounds led to the development of potent BET bromodomain inhibitors with excellent activity against leukemic cells, concomitant with a reduction in c- MYC expression.

These novel benzodiazepines therefore represent a promising class of therapeutic BET inhibitors. Time-dependent anisotropic distributed source capability in transient 3-d transport code tort- TD. The transient 3-D discrete ordinates transport code TORT- TD has been extended to account for time-dependent anisotropic distributed external sources. Since feedback effects are not relevant in this zero-power configuration, this offers a unique opportunity to validate the time-dependent neutron kinetics of TORT- TD with experimental data.

The steady state of the YALINA-Thermal assembly and its response to an artificial square-wave source pulse sequence have been analysed with TORT- TD using pin-wise homogenised cross sections in 18 prompt energy groups with P 1 scattering order and 8 delayed neutron groups. The TD 50 concept was introduced by Peto R.

Using TD 50 values available for substances, the procedure presented here allows one to determine OLVs corresponding to a fixed excess risk. It is based on a mathematical high-to-low doses extrapolation of the TD OLVs obtained with this procedure are compared with currently available TLVs and other occupational guidelines. Editorial Scott Ergonomics SA. Username, Password, Remember me, or Register. Here we show effect of the polyamine polymer chain length to BET isotherms.

Bet -hedging response to environmental variability, an intraspecific comparison. A major challenge in ecology is to understand the impact of increased environmental variability on populations and ecosystems. To maximize their fitness in a variable environment, life history theory states that individuals should favor a bet -hedging strategy, involving a reduction of annual breeding performance and an increase in adult survival so that reproduction can be attempted over more years.

As a result, evolution toward longer life span is expected to reduce the deleterious effects of extra variability on population growth, and consequently on the trait contributing the most to it e. To investigate this, we compared the life histories of two Black-browed Albatross Thalassarche melanophrys populations breeding at South Georgia Atlantic Ocean and Kerguelen Indian Ocean , the former in an environment nearly three times more variable climatically e.

As predicted, individuals from South Georgia in the more variable environment showed significantly higher annual adult survival 0. In both populations, climatic conditions affected the breeding success and the survival of inexperienced breeders, whereas the survival of experienced breeders was unaffected. The strength of the climatic impact on survival of inexperienced breeders was very similar between the two populations, but the effect on breeding success was positively related to environmental variability.

These results provide rare and compelling evidence to support bet -hedging underlying changes in life history traits as an adaptive response to environmental variability. In natural and social science, many events happened at different space-times may be closely correlated. The Ps Td invariant solution show that the event happened at A will happen also at B.

These solutions, such as single soliton solutions, infinitely many singular soliton solutions, soliton-cnoidal wave interaction solutions, and symmetry reduction solutions etc. Full Text Available BET family proteins are epigenetic regulators known to control expression of genes involved in cell growth and oncogenesis.

Selective inhibitors of BET proteins exhibit potent anti-proliferative activity in a number of hematologic cancer models, in part through suppression of the MYC oncogene and downstream Myc-driven pathways. However, little is currently known about the activity of BET inhibitors in solid tumor models, and whether down-regulation of MYC family genes contributes to sensitivity.

Here we provide evidence for potent BET inhibitor activity in neuroblastoma, a pediatric solid tumor associated with a high frequency of MYCN amplifications. Oral administration of I- BET to mouse xenograft models of human neuroblastoma results in tumor growth inhibition and down-regulation MYCN and BCL2 expression, suggesting a potential role for these genes in tumor growth. Taken together, our data highlight the potential of BET inhibitors as novel therapeutics for neuroblastoma, and suggest that sensitivity is driven by pleiotropic effects on cell growth and apoptotic pathways in a context-specific manner.

CTF is a transient code based on a separated flow representation of the two-phase flow. The steady state cases are based on a quarter core model while the transient test case models a control rod ejection transient in a small PWR mini-core fuel assembly arrangement. BET bromodomain inhibition reduces maturation and enhances tolerogenic properties of human and mouse dendritic cells. Transcription of inflammatory genes is tightly regulated by acetylation and deacetylation of histone tails.

An inhibitor of the acetylated-lysine reader bromodomain and extra-terminal domain BET proteins, I- BET , is known to counteract the induction of expression of inflammatory genes in. Full Text Available A synthetic gene encoding bovine terminal deoxynucleotidyl transferase Td T was generated, cloned into an expression vector and expressed in E. The effects of altering culture and induction conditions on the nature of recombinant protein production were investigated.

This led to the expression of active recombinant bovine Td T in E. After purification and characterisation, the activity of the enzyme was assessed in a biological assay for apoptosis. The process described in this report enables the economical production of Td T for high throughput applications.

Ergonomics SA : Site Map. ISSN: Metallographic examination of TD -nickel base alloys. Techniques are evaluated for chemical, electrochemical, and thermal etching of thoria dispersed TD nickel alloys. An electrochemical etch is described which yielded good results only for large grain sizes of TD -nickel. Two types of thermal etches are assessed for TD -nickel: an oxidation etch and vacuum annealing of a polished specimen to produce an etch.

It is shown that the first etch was somewhat dependent on sample orientation with respect to the processing direction, the second technique was not sensitive to specimen orientation or grain size, and neither method appear to alter the innate grain structure when the materials were fully annealed prior to etching. An electrochemical etch is described which was used to observe the microstructures in TD -NiCr, and a thermal-oxidation etch is shown to produce better detail of grain boundaries and to have excellent etching behavior over the entire range of grain sizes of the sample.

Here, we generated a floxed STOP td Tomato rat that conditionally expresses a red fluorescent protein variant td Tomato in the presence of exogenous Cre recombinase. The td Tomato signal vividly visualizes neurons including their projection fibers and spines without any histological enhancement.

Our rat reporter system will facilitate connectome studies as well as the visualization of the fine structures of genetically identified cells for long periods both in vivo and ex vivo. This new phenomenon has not been revealed in the scie Til brug for sine overvejelser har kommissionen Bet OnMath azzardo e matematica a scuola. Why do people gamble?

A large body of research suggests that cognitive distortions play an important role in pathological gambling. Many of these distortions are specific cases of a more general misperception of randomness, specifically of an illusory perception of patterns in random sequences. In this article, we provide further evidence for the assumption that gamblers are particularly prone to perceiving illusory patterns.

In particular, we compared habitual gamblers to a matched sample of community members with regard to how much they exhibit the choice anomaly 'probability matching'. Probability matching describes the tendency to match response proportions to outcome probabilities when predicting binary outcomes. It leads to a lower expected accuracy than the maximizing strategy of predicting the most likely event on each trial. Previous research has shown that an illusory perception of patterns in random sequences fuels probability matching.

So does impulsivity, which is also reported to be higher in gamblers. We therefore hypothesized that gamblers will exhibit more probability matching than non-gamblers, which was confirmed in a controlled laboratory experiment.

Additionally, gamblers scored much lower than community members on the cognitive reflection task, which indicates higher impulsivity. This difference could account for the difference in probability matching between the samples. These results suggest that gamblers are more willing to bet impulsively on perceived illusory patterns.

While couched in the framework of concentrating minds betting on natural hazards carries an ethical cost. When children dare each other to do risky things parents know that when such dares are taken harm frequently occurs. Giving those who claim that there is no hazard financial reasons to avoid ameliorative actions or to double down in support of their public stance requires a moral calculation. Challenging the conclusions of those who accept such bets while denying danger will lead them to attempt to save face by increasing risk to themselves or others.

Thus such wagers, whether person to person or on betting markets, require balancing between alerting the opposing party and others to the risks of not taking action, the associated scientific consensus and the possible harmful outcomes of the bets themselves. This talk will describe strategies for minimizing potential harm while maximizing the instructive component of climate bets. Best practices include having the bet rest on a technical issue that can be authoritatively resolved in a short time.

Unfortunately the nature of natural hazard risks makes it difficult to meet all of these criteria, but those making such bets should be aware of the ethical double bind. Minimal research has been published about inducements for sports and race betting , despite their ready availability and aggressive advertising.

This paper aimed to document the range and structural features of these inducements, and analyse their alignment with the harm minimisation and consumer protection goals of responsible gambling. A scan of all inducements offered on the websites of 30 major race and sports betting brands located separate inducements which we categorised into 15 generic types, all offering financial incentives to purchase.

All inducements were subject to numerous terms and conditions which were complex, difficult to find, and obscured by legalistic language. Play-through conditions of bonus bets were particularly difficult to interpret and failed basic requirements for informed choice. Website advertisements for inducements were prominently promoted but few contained a responsible gambling message.

The results were analysed to generate 12 research propositions considered worthy of empirical research to inform much needed regulatory reform in this area. Kharenko, Olesya A. Bromodomains are epigenetic readers that specifically bind to the acetyl lysine residues of histones and transcription factors. Small molecule BET bromodomain inhibitors can disrupt this interaction which leads to potential modulation of several disease states.

Here we describe the binding properties of a novel BET inhibitor RVX that is structurally related to the clinical compound RVX, currently undergoing phase III clinical trials for the treatment of cardiovascular diseases, but is distinctly different in its biological and pharmacokinetic profiles. Betting odds are frequently found to outperform mathematical models in sports related forecasting tasks, however the factors contributing to betting odds are not fully traceable and in contrast to rating-based forecasts no straightforward measure of team-specific quality is deducible from the betting odds.

The present study investigates the approach of combining the methods of mathematical models and the information included in betting odds. A soccer forecasting model based on the well-known ELO rating system and taking advantage of betting odds as a source of information is presented.

Data from almost The novel betting odds based ELO model is shown to outperform classic ELO models, thus demonstrating that betting odds prior to a match contain more relevant information than the result of the match itself. It is shown how the novel model can help to gain valuable insights into the quality of soccer teams and its development over time, thus having a practical benefit in performance analysis.

Moreover, it is argued that network based approaches might help in further improving rating and forecasting methods. Recome S. What do children observe and learn from televised sports betting advertisements? A qualitative study among Australian children.

To explore children's awareness of sports betting advertising and how this advertising may influence children's attitudes, product knowledge and desire to try sports betting. Semi-structured qualitative interviews were conducted with 48 children years from Melbourne, Victoria. The interview schedule explored children's recall and interpretations of sports betting advertising, strategies within advertisements that may appeal to children, children's product knowledge and understanding of betting terminology, and factors that may encourage gambling.

Interviews were transcribed and thematic analysis was conducted. Children recalled in detail sports betting advertisements that they had seen, with humour the most engaging appeal strategy. They were also able to describe other specific appeal strategies and link these strategies to betting brands.

Many children described how advertisements demonstrated how someone would place a bet , with some children recalling the detailed technical language associated with betting. Children had detailed recall of sports betting advertisements and an extensive knowledge of sports betting products and terminology. Implications for public health: To protect children from the potential harms associated with sports betting , governments should consider changing regulations and implementing evidence-based education campaigns to counter the positive messages children receive from the sports betting industry.

Finding the right alternative BET settings can be a difficult and time-con The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands. Full Text Available Abstract Background The major birch pollen allergen, Bet v 1, is a member of the ubiquitous PR family of plant pathogenesis-related proteins.

In recent years, a number of diverse plant proteins with low sequence similarity to Bet v 1 was identified. In addition, determination of the Bet v 1 structure revealed the existence of a large superfamily of structurally related proteins.

In this study, we aimed to identify and classify all Bet v 1-related structures from the Protein Data Bank and all Bet v 1-related sequences from the Uniprot database. Results Structural comparisons of representative members of already known protein families structurally related to Bet v 1 with all entries of the Protein Data Bank yielded 47 structures with non-identical sequences. They were classified into eleven families, five of which were newly identified and not included in the Structural Classification of Proteins database release 1.

The taxonomic distribution of these families extracted from the Pfam protein family database showed that members of the polyketide cyclase family and the activator of Hsp90 ATPase homologue 1 family were distributed among all three superkingdoms, while members of some bacterial families were confined to a small number of species. Comparison of ligand binding activities of Bet v 1-like superfamily members revealed that their functions were related to binding and metabolism of large, hydrophobic compounds such as lipids, hormones, and antibiotics.

Phylogenetic relationships within the Bet v 1 family, defined as the group of proteins with significant sequence similarity to Bet v 1, were determined by aligning Bet v 1-related sequences. A distance-based phylogenetic tree yielded a classification into 11 subfamilies, nine exclusively containing plant sequences and two subfamilies of bacterial proteins. Biosynthesis and characterization of polyhydroxyalkanoates copolymers produced by Pseudomonas putida Bet isolated from palm oil mill effluent.

Full Text Available The biosynthesis and characterization of medium chain length polyhydroxyalkanoates mcl-PHA produced by Pseudomonas putida Bet isolated from palm oil mill effluent was studied. The biosynthesis of mcl-PHA in this newly isolated microorganism follows a growth-associated trend.

Mcl-PHA accumulation ranging from Molecular weight of the polymer was found to be ranging from No unsaturated monomer was detected. Thermo-chemical analyses showed the accumulated PHA to be semi-crystalline polymer with good thermal stability, having a thermal degradation temperature T d of The biosynthesis and characterization of medium chain length polyhydroxyalkanoates mcl-PHA produced by Pseudomonas putida Bet isolated from palm oil mill effluent was studied.

Bet Dwarka Island is situated on the extreme west of Indian territory in Jamnagar district of Gujarat. Underwater, the most preserved remains of ancient maritime activity could be the stone anchors of different types, as every boat requires Umadevi, P. Abdul; Kumar, J.

Krishna; Sreekumar, Sreejith; Basim, A. A new system was designed, realised and qualified meeting the mission requirements of RLV- TD , at the same time taking advantage of the flight heritage attained in INS through various Launch vehicle Missions of the country. The new system has additional redundancy in acceleration channel, in-built inclinometer based bias update scheme for acceleration channels and sign conventions as employed in an aircraft. Data acquisition in micro cycle periodicity 10 ms was incorporated which was required to provide rate and attitude information at higher sampling rate for ascent phase control.

Provision was incorporated for acquisition of rate and acceleration data with high resolution for aerodynamic characterisation and parameter estimation. GPS aided navigation scheme was incorporated to meet the stringent accuracy requirements of the mission. Navigation system configuration for RLV- TD , specific features incorporated to meet the mission requirements, various tests carried out and performance during RLV- TD flight are highlighted. BET bromodomain inhibition promotes neurogenesis while inhibiting gliogenesis in neural progenitor cells.

Bundesliga - End of Season 2. Liga 3. Liga - Tips 3. Liga - Match Day Tips 3. Liga - Teams 3. Liga - End of Season 3. Liga - Odds Comparison. Odds Value Bet Finder. Probabilities for home win, draw, and away team. Arsenal ARS. Leeds LEE. Brighton BRI. Aston Villa AST. Chelsea CHE.

Newcastle NEW. Palace CRY. Burnley BUR. Everton EVE. Leicester LEI. Liverpool LIV. Man City MC. Tottenham TOT. West Bromw. Man United MU. West Ham WHA. Sheffield U. The three most likely results. KickForm score recommendations for your tip game. Premier League. Champion Prognosis. Champions League Prognosis.

Relegation Prognosis. Current football predictions and tips KickForm.

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The steady state of the YALINA-Thermal assembly and its response to an artificial square-wave source pulse sequence have been analysed with TORT- TD using pin-wise homogenised cross sections in 18 prompt energy groups with P 1 scattering order and 8 delayed neutron groups. The TD 50 concept was introduced by Peto R. Using TD 50 values available for substances, the procedure presented here allows one to determine OLVs corresponding to a fixed excess risk.

It is based on a mathematical high-to-low doses extrapolation of the TD OLVs obtained with this procedure are compared with currently available TLVs and other occupational guidelines. Editorial Scott Ergonomics SA.

Username, Password, Remember me, or Register. Here we show effect of the polyamine polymer chain length to BET isotherms. Bet -hedging response to environmental variability, an intraspecific comparison. A major challenge in ecology is to understand the impact of increased environmental variability on populations and ecosystems. To maximize their fitness in a variable environment, life history theory states that individuals should favor a bet -hedging strategy, involving a reduction of annual breeding performance and an increase in adult survival so that reproduction can be attempted over more years.

As a result, evolution toward longer life span is expected to reduce the deleterious effects of extra variability on population growth, and consequently on the trait contributing the most to it e. To investigate this, we compared the life histories of two Black-browed Albatross Thalassarche melanophrys populations breeding at South Georgia Atlantic Ocean and Kerguelen Indian Ocean , the former in an environment nearly three times more variable climatically e.

As predicted, individuals from South Georgia in the more variable environment showed significantly higher annual adult survival 0. In both populations, climatic conditions affected the breeding success and the survival of inexperienced breeders, whereas the survival of experienced breeders was unaffected.

The strength of the climatic impact on survival of inexperienced breeders was very similar between the two populations, but the effect on breeding success was positively related to environmental variability. These results provide rare and compelling evidence to support bet -hedging underlying changes in life history traits as an adaptive response to environmental variability. In natural and social science, many events happened at different space-times may be closely correlated.

The Ps Td invariant solution show that the event happened at A will happen also at B. These solutions, such as single soliton solutions, infinitely many singular soliton solutions, soliton-cnoidal wave interaction solutions, and symmetry reduction solutions etc.

Full Text Available BET family proteins are epigenetic regulators known to control expression of genes involved in cell growth and oncogenesis. Selective inhibitors of BET proteins exhibit potent anti-proliferative activity in a number of hematologic cancer models, in part through suppression of the MYC oncogene and downstream Myc-driven pathways. However, little is currently known about the activity of BET inhibitors in solid tumor models, and whether down-regulation of MYC family genes contributes to sensitivity.

Here we provide evidence for potent BET inhibitor activity in neuroblastoma, a pediatric solid tumor associated with a high frequency of MYCN amplifications. Oral administration of I- BET to mouse xenograft models of human neuroblastoma results in tumor growth inhibition and down-regulation MYCN and BCL2 expression, suggesting a potential role for these genes in tumor growth.

Taken together, our data highlight the potential of BET inhibitors as novel therapeutics for neuroblastoma, and suggest that sensitivity is driven by pleiotropic effects on cell growth and apoptotic pathways in a context-specific manner. CTF is a transient code based on a separated flow representation of the two-phase flow.

The steady state cases are based on a quarter core model while the transient test case models a control rod ejection transient in a small PWR mini-core fuel assembly arrangement. BET bromodomain inhibition reduces maturation and enhances tolerogenic properties of human and mouse dendritic cells. Transcription of inflammatory genes is tightly regulated by acetylation and deacetylation of histone tails.

An inhibitor of the acetylated-lysine reader bromodomain and extra-terminal domain BET proteins, I- BET , is known to counteract the induction of expression of inflammatory genes in. Full Text Available A synthetic gene encoding bovine terminal deoxynucleotidyl transferase Td T was generated, cloned into an expression vector and expressed in E.

The effects of altering culture and induction conditions on the nature of recombinant protein production were investigated. This led to the expression of active recombinant bovine Td T in E. After purification and characterisation, the activity of the enzyme was assessed in a biological assay for apoptosis. The process described in this report enables the economical production of Td T for high throughput applications.

Ergonomics SA : Site Map. ISSN: Metallographic examination of TD -nickel base alloys. Techniques are evaluated for chemical, electrochemical, and thermal etching of thoria dispersed TD nickel alloys. An electrochemical etch is described which yielded good results only for large grain sizes of TD -nickel.

Two types of thermal etches are assessed for TD -nickel: an oxidation etch and vacuum annealing of a polished specimen to produce an etch. It is shown that the first etch was somewhat dependent on sample orientation with respect to the processing direction, the second technique was not sensitive to specimen orientation or grain size, and neither method appear to alter the innate grain structure when the materials were fully annealed prior to etching.

An electrochemical etch is described which was used to observe the microstructures in TD -NiCr, and a thermal-oxidation etch is shown to produce better detail of grain boundaries and to have excellent etching behavior over the entire range of grain sizes of the sample.

Here, we generated a floxed STOP td Tomato rat that conditionally expresses a red fluorescent protein variant td Tomato in the presence of exogenous Cre recombinase. The td Tomato signal vividly visualizes neurons including their projection fibers and spines without any histological enhancement. Our rat reporter system will facilitate connectome studies as well as the visualization of the fine structures of genetically identified cells for long periods both in vivo and ex vivo. This new phenomenon has not been revealed in the scie Til brug for sine overvejelser har kommissionen Bet OnMath azzardo e matematica a scuola.

Why do people gamble? A large body of research suggests that cognitive distortions play an important role in pathological gambling. Many of these distortions are specific cases of a more general misperception of randomness, specifically of an illusory perception of patterns in random sequences. In this article, we provide further evidence for the assumption that gamblers are particularly prone to perceiving illusory patterns.

In particular, we compared habitual gamblers to a matched sample of community members with regard to how much they exhibit the choice anomaly 'probability matching'. Probability matching describes the tendency to match response proportions to outcome probabilities when predicting binary outcomes. It leads to a lower expected accuracy than the maximizing strategy of predicting the most likely event on each trial.

Previous research has shown that an illusory perception of patterns in random sequences fuels probability matching. So does impulsivity, which is also reported to be higher in gamblers. We therefore hypothesized that gamblers will exhibit more probability matching than non-gamblers, which was confirmed in a controlled laboratory experiment.

Additionally, gamblers scored much lower than community members on the cognitive reflection task, which indicates higher impulsivity. This difference could account for the difference in probability matching between the samples. These results suggest that gamblers are more willing to bet impulsively on perceived illusory patterns. While couched in the framework of concentrating minds betting on natural hazards carries an ethical cost.

When children dare each other to do risky things parents know that when such dares are taken harm frequently occurs. Giving those who claim that there is no hazard financial reasons to avoid ameliorative actions or to double down in support of their public stance requires a moral calculation.

Challenging the conclusions of those who accept such bets while denying danger will lead them to attempt to save face by increasing risk to themselves or others. Thus such wagers, whether person to person or on betting markets, require balancing between alerting the opposing party and others to the risks of not taking action, the associated scientific consensus and the possible harmful outcomes of the bets themselves.

This talk will describe strategies for minimizing potential harm while maximizing the instructive component of climate bets. Best practices include having the bet rest on a technical issue that can be authoritatively resolved in a short time.

Unfortunately the nature of natural hazard risks makes it difficult to meet all of these criteria, but those making such bets should be aware of the ethical double bind. Minimal research has been published about inducements for sports and race betting , despite their ready availability and aggressive advertising. This paper aimed to document the range and structural features of these inducements, and analyse their alignment with the harm minimisation and consumer protection goals of responsible gambling.

A scan of all inducements offered on the websites of 30 major race and sports betting brands located separate inducements which we categorised into 15 generic types, all offering financial incentives to purchase. All inducements were subject to numerous terms and conditions which were complex, difficult to find, and obscured by legalistic language.

Play-through conditions of bonus bets were particularly difficult to interpret and failed basic requirements for informed choice. Website advertisements for inducements were prominently promoted but few contained a responsible gambling message. The results were analysed to generate 12 research propositions considered worthy of empirical research to inform much needed regulatory reform in this area. Kharenko, Olesya A. Bromodomains are epigenetic readers that specifically bind to the acetyl lysine residues of histones and transcription factors.

Small molecule BET bromodomain inhibitors can disrupt this interaction which leads to potential modulation of several disease states. Here we describe the binding properties of a novel BET inhibitor RVX that is structurally related to the clinical compound RVX, currently undergoing phase III clinical trials for the treatment of cardiovascular diseases, but is distinctly different in its biological and pharmacokinetic profiles.

Betting odds are frequently found to outperform mathematical models in sports related forecasting tasks, however the factors contributing to betting odds are not fully traceable and in contrast to rating-based forecasts no straightforward measure of team-specific quality is deducible from the betting odds.

The present study investigates the approach of combining the methods of mathematical models and the information included in betting odds. A soccer forecasting model based on the well-known ELO rating system and taking advantage of betting odds as a source of information is presented. Data from almost The novel betting odds based ELO model is shown to outperform classic ELO models, thus demonstrating that betting odds prior to a match contain more relevant information than the result of the match itself.

It is shown how the novel model can help to gain valuable insights into the quality of soccer teams and its development over time, thus having a practical benefit in performance analysis. Moreover, it is argued that network based approaches might help in further improving rating and forecasting methods. Recome S. What do children observe and learn from televised sports betting advertisements? A qualitative study among Australian children. To explore children's awareness of sports betting advertising and how this advertising may influence children's attitudes, product knowledge and desire to try sports betting.

Semi-structured qualitative interviews were conducted with 48 children years from Melbourne, Victoria. The interview schedule explored children's recall and interpretations of sports betting advertising, strategies within advertisements that may appeal to children, children's product knowledge and understanding of betting terminology, and factors that may encourage gambling. Interviews were transcribed and thematic analysis was conducted. Children recalled in detail sports betting advertisements that they had seen, with humour the most engaging appeal strategy.

They were also able to describe other specific appeal strategies and link these strategies to betting brands. Many children described how advertisements demonstrated how someone would place a bet , with some children recalling the detailed technical language associated with betting. Children had detailed recall of sports betting advertisements and an extensive knowledge of sports betting products and terminology. Implications for public health: To protect children from the potential harms associated with sports betting , governments should consider changing regulations and implementing evidence-based education campaigns to counter the positive messages children receive from the sports betting industry.

Finding the right alternative BET settings can be a difficult and time-con The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands. Full Text Available Abstract Background The major birch pollen allergen, Bet v 1, is a member of the ubiquitous PR family of plant pathogenesis-related proteins. In recent years, a number of diverse plant proteins with low sequence similarity to Bet v 1 was identified.

In addition, determination of the Bet v 1 structure revealed the existence of a large superfamily of structurally related proteins. In this study, we aimed to identify and classify all Bet v 1-related structures from the Protein Data Bank and all Bet v 1-related sequences from the Uniprot database. Results Structural comparisons of representative members of already known protein families structurally related to Bet v 1 with all entries of the Protein Data Bank yielded 47 structures with non-identical sequences.

They were classified into eleven families, five of which were newly identified and not included in the Structural Classification of Proteins database release 1. The taxonomic distribution of these families extracted from the Pfam protein family database showed that members of the polyketide cyclase family and the activator of Hsp90 ATPase homologue 1 family were distributed among all three superkingdoms, while members of some bacterial families were confined to a small number of species.

Comparison of ligand binding activities of Bet v 1-like superfamily members revealed that their functions were related to binding and metabolism of large, hydrophobic compounds such as lipids, hormones, and antibiotics. Phylogenetic relationships within the Bet v 1 family, defined as the group of proteins with significant sequence similarity to Bet v 1, were determined by aligning Bet v 1-related sequences.

A distance-based phylogenetic tree yielded a classification into 11 subfamilies, nine exclusively containing plant sequences and two subfamilies of bacterial proteins. Biosynthesis and characterization of polyhydroxyalkanoates copolymers produced by Pseudomonas putida Bet isolated from palm oil mill effluent.

Full Text Available The biosynthesis and characterization of medium chain length polyhydroxyalkanoates mcl-PHA produced by Pseudomonas putida Bet isolated from palm oil mill effluent was studied. The biosynthesis of mcl-PHA in this newly isolated microorganism follows a growth-associated trend. Mcl-PHA accumulation ranging from Molecular weight of the polymer was found to be ranging from No unsaturated monomer was detected. Thermo-chemical analyses showed the accumulated PHA to be semi-crystalline polymer with good thermal stability, having a thermal degradation temperature T d of The biosynthesis and characterization of medium chain length polyhydroxyalkanoates mcl-PHA produced by Pseudomonas putida Bet isolated from palm oil mill effluent was studied.

Bet Dwarka Island is situated on the extreme west of Indian territory in Jamnagar district of Gujarat. Underwater, the most preserved remains of ancient maritime activity could be the stone anchors of different types, as every boat requires Umadevi, P. Abdul; Kumar, J. Krishna; Sreekumar, Sreejith; Basim, A. A new system was designed, realised and qualified meeting the mission requirements of RLV- TD , at the same time taking advantage of the flight heritage attained in INS through various Launch vehicle Missions of the country.

The new system has additional redundancy in acceleration channel, in-built inclinometer based bias update scheme for acceleration channels and sign conventions as employed in an aircraft. Data acquisition in micro cycle periodicity 10 ms was incorporated which was required to provide rate and attitude information at higher sampling rate for ascent phase control. Provision was incorporated for acquisition of rate and acceleration data with high resolution for aerodynamic characterisation and parameter estimation.

GPS aided navigation scheme was incorporated to meet the stringent accuracy requirements of the mission. Navigation system configuration for RLV- TD , specific features incorporated to meet the mission requirements, various tests carried out and performance during RLV- TD flight are highlighted.

BET bromodomain inhibition promotes neurogenesis while inhibiting gliogenesis in neural progenitor cells. Full Text Available Neural stem cells and progenitor cells NPCs are increasingly appreciated to hold great promise for regenerative medicine to treat CNS injuries and neurodegenerative diseases.

However, evidence for effective stimulation of neuronal production from endogenous or transplanted NPCs for neuron replacement with small molecules remains limited. Through screening small molecule libraries with annotated targets, we identified BET bromodomain inhibition as a novel mechanism for enhancing neurogenesis. Gene expression profiling analysis demonstrated that BET bromodomain inhibition induced a broad but specific transcription program enhancing directed differentiation of NPCs into neurons while suppressing cell cycle progression and gliogenesis.

Together, these results highlight a crucial role of BET proteins as epigenetic regulators in NPC development and suggest a therapeutic potential of BET inhibitors in treating brain injuries and neurodegenerative diseases. BET inhibitors in metastatic prostate cancer: therapeutic implications and rational drug combinations.

The bromodomain and extra-terminal BET family of proteins are epigenetic readers of acetylated histones regulating a vast network of protein expression across many different cancers. Therapeutic targeting of BET is an attractive area of clinical development for metastatic castration-resistant prostate cancer mCRPC , particularly due to its putative effect on c-MYC expression and its interaction with the androgen receptor AR. Areas covered: We speculate that a combination approach using inhibitors of BET proteins BETi with other targeted therapies may be required to improve the therapeutic index of BET inhibition in the management of prostate cancer.

Preclinical data has identified several molecular targets that may enhance the effect of BET inhibition in the clinic. This review will summarize the known preclinical data implicating BET as an important therapeutic target in advanced prostate cancer, highlight the ongoing clinical trials targeting this protein family, and speculate on rationale combination strategies using BETi together with other agents in prostate cancer.

A literature search using Pubmed was performed for this review. Full Text Available Complexity in mainstream economics consists in high intermediary consumption of mathematics. A new approach to complexity economics dwells upon path-dependent global systems; their emergence and evolving organisation. The focus here is on the complexity of the real economic world due to globalisation. On-line betting related match-fixing is a case in point about which the article presents non-exhaustive empirical evidence and shows how it is analysed with the standard model of the economics of crime.

There is no room for complexity in such an individualistic approach to corrupt behaviour applied to bet -related fixes. A more complex model is sketched based on interactions between a global though underground market for fixes and the actual partly legal, partly illegal global sport betting market.

These interactions exhibit how complex is the issue of combating betting -related match fixing. The novelty in this approach is a variable increasing rate applied to increasing tranches of taxation gains which should dry up the worst cases of on-line bettingrelated match fixing.

Gambling is one of the favourite leisure activities. Over the last few years, however, the variety of opportunities to gamble has changed. Decreasing numbers of casino visitors can be seen against an ever-increasing number of people using slot machines, and taking part in national lotteries and sport betting. Comprehensive empirical research regarding consumer behaviour and addiction potential involved in sport betting has been non-existent and only a few studies have dealt with lottery.

In the present study, subjects were questioned in Austrian betting offices. Of the sport betting subjects who additionally play lottery, Based on the criteria of substance addiction, the data demonstrate that sport betting and lottery have addiction potential and can therefore be seen as non-substance-related addiction.

This paper aims to update the information available on the lithic assemblage from the entire sequence of TD 6 now that the most recent excavations have been completed, and to explore possible changes in both occupational patterns and technological strategies evidenced in the unit. This is the first study to analyse the entire TD 6 sequence, including subunits TD 6. We also present an analysis of several lithic refits found in TD 6, as well as certain technical features that may help characterise the hominin occupations.

The archaeo-palaeontological record from TD 6 consists of 9, faunal remains, coprolites, 1, lithic pieces, hominin remains and 91 Celtis seeds. The characteristics of this record seem to indicate two main stages of occupation. In the oldest subunit, TD 6. In contrast, the lithic assemblages from TD 6. Despite the occupational differences between the lowermost subunit and the rest of the deposit, technologically the TD 6 lithic assemblage is extremely homogeneous throughout.

In addition, the composition and spatial distribution of the 12 groups of lithic refits found in unit TD 6, as well as the in situ nature of the assemblage demonstrate the high degree of preservation at the site. This may help clarify the nature of the Early Pleistocene hominin occupations of TD 6, and raise reasonable doubt about the latest interpretations that support the ex situ character of the assemblage as a whole.

Full Text Available In order to solve the security problem of transmission image across public networks, a new image encryption algorithm based on TD -ERCS system and wavelet neural network is proposed in this paper. According to the permutation process and the binary XOR operation from the chaotic series by producing TD -ERCS system and wavelet neural network, it can achieve image encryption.

This encryption algorithm is a reversible algorithm, and it can achieve original image in the rule inverse process of encryption algorithm. Finally, through computer simulation, the experiment results show that the new chaotic encryption algorithm based on TD -ERCS system and wavelet neural network is valid and has higher security.

This paper describes the implementation of a time-dependent distributed external source in TORT- TD by explicitly considering the external source in the ''fixed-source'' term of the implicitly time-discretised 3-D discrete ordinates transport equation. Anisotropy of the external source is represented by a spherical harmonics series expansion similar to the angular fluxes. Good agreement is achieved concerning the multiplication factor. The response of the system to an artificial time-dependent source consisting of two square-wave pulses demonstrates the time-dependent external source capability of TORT- TD.

The result is physically plausible as judged from validation calculations. As a result, we experienced rolling outages for a few months in the Tokyo and Tohoku area. As a result, the Japanese Electricity System Reform policy was adopted. Knowledge of these elements has a strong impact on the unitarity triangle, of interest for studies of CP violation in the B system.

During fieldwork conducted with workers and customers in betting shops in London research participants consistently conceptualized betting shops as masculine spaces in contrast to the femininity of other places including home and the bingo hall. According to this argument, betting on horses and dogs was 'men's business' and betting shops were 'men's worlds'. Two explanations were offered to account for this situation. The first suggested that betting was traditionally a pastime enjoyed by men rather than women.

The second was that betting is intrinsically more appealing to men because it is based on calculation and measurement, and women prefer more intuitive, simpler challenges. I use interviews with older people to describe how the legalisation of betting in cash in changed the geography of betting. I then draw upon interviews with regular customers in order to show how knowledge about betting is shared within rather than between genders. Finally, I use my experience of training and working as a cashier to describe how the particular hegemonic masculinity found in betting shops in London is maintained through myriad everyday practices which reward certain kinds of gendered performances while at the same time suppressing alternatives.

The article shows how particular spaces may become gendered as an unanticipated consequence of legislation and how contingent gendered associations are both naturalized and, at the same time, subjected to intense attention. Sports betting marketing during sporting events: a stadium and broadcast census of Australian Football League matches.

Using Australian Football League AFL matches as a case study, we investigated the frequency, length and content of marketing strategies for sports betting during two specific settings: 1 at stadiums during four live matches; and 2 during eight televised broadcasts of matches. Census of sports betting marketing during Round 12 of the AFL premiership season.

Per match, there was an average of A diverse range of marketing techniques were used to: a embed sports betting within the game; b align sports betting with fans' overall experience of the game; and c encourage individuals to bet live during the game.

There were very few visible or audible messages such as responsible gambling or Gambler's Help messages to counter-frame the overwhelmingly positive messages that individuals received about sports betting during the match. This study raises important questions about the impacts of saturation, integrated and impulse gambling marketing strategies in sporting matches.

Future research should explore: 1 how wagering industry marketing strategies may affect the attitudes and behaviours of community sub-groups e. Full Text Available This article is about the design of controllers for magnetic levitation Maglev system in both simulation and real time. Local linearization around the equilibrium point has been done for the nonlinear Maglev system to obtain a linearized model transfer function.

In this study, the design of integral-tilted-derivative I- TD controller has been proposed for the Maglev system and its performance is compared with conventional tilted-integral-derivative TID controller. In this study, TID controller parameters have been optimized through genetic algorithm GA and those set of values have been employed for the design of I- TD controller.

The analysis shows the superiority of I- TD controller over TID controller in terms of maximum overshoot, gain margin and phase margin. The settling time remains almost same in both the cases. In future, a detailed study of robustness in presence of model uncertainties will be incorporated as a scope of further research.

Td PIR minisatellite fingerprinting as a useful new tool for Torulaspora delbrueckii molecular typing. Torulaspora delbrueckii yeast strains are being increasingly applied at the industrial level, such as in the winemaking process, and so their identification and characterisation require effective, fast, accurate, reproducible and reliable approaches.

Therefore, the development of typing techniques that allow discrimination at the strain level will provide an essential tool for those working with T. Here, 28 T. The aim was to determine and compare the efficacies, reproducibilities and discriminating powers of these molecular methods. Moreover, the Td PIR3 primers showed reproducible profiles when the stringency of the PCR protocol was varied, which highlighted the great robustness of this technique.

In contrast, variation of the stringency of the M13 PCR protocol resulted in modification of the amplified profiles, which suggested low reproducibility of this technique. Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice. Lee, Dong U. Through their bromodomain, these proteins bind to acetylated lysine residues of histones and are recruited to transcriptionally active chromatin.

Inhibition of the BET -histone interaction provides a tractable therapeutic strategy to treat diseases that may have epigenetic dysregulation. JQ1 is a small molecule that blocks BET interaction with histones. It has been shown to decrease proliferation of patient-derived multiple myeloma in vitro and to decrease tumor burden in vivo in xenograft mouse models. While targeting BET appears to be a viable and efficacious approach, the nonclinical safety profile of BET inhibition remains to be well-defined.

We report that mice dosed with JQ1 at efficacious exposures demonstrate dose-dependent decreases in their lymphoid and immune cell compartments. At higher doses, JQ1 was not tolerated and due to induction of significant body weight loss led to early euthanasia. Flow cytometry analysis of lymphoid tissues showed a decrease in both B- and T-lymphocytes with a concomitant decrease in peripheral white blood cells that was confirmed by hematology.

Further investigation with the inactive enantiomer of JQ1 showed that these in vivo effects were on-target mediated and not elicited through secondary pharmacology due to chemical structure. Bet hedging in yeast by heterogeneous, age-correlated expression of a stress protectant. Full Text Available Genetically identical cells grown in the same culture display striking cell-to-cell heterogeneity in gene expression and other traits. A crucial challenge is to understand how much of this heterogeneity reflects the noise tolerance of a robust system and how much serves a biological function.

In bacteria, stochastic gene expression results in cell-to-cell heterogeneity that might serve as a bet -hedging mechanism, allowing a few cells to survive through an antimicrobial treatment while others perish. Despite its clinical importance, the molecular mechanisms underlying bet hedging remain unclear. Here, we investigate the mechanisms of bet hedging in Saccharomyces cerevisiae using a new high-throughput microscopy assay that monitors variable protein expression, morphology, growth rate, and survival outcomes of tens of thousands of yeast microcolonies simultaneously.

We find that clonal populations display broad distributions of growth rates and that slow growth predicts resistance to heat killing in a probabalistic manner. We identify several gene products that are likely to play a role in bet hedging and confirm that Tsl1, a trehalose-synthesis regulator, is an important component of this resistance. Tsl1 abundance correlates with growth rate and replicative age and predicts survival.

Our results suggest that yeast bet hedging results from multiple epigenetic growth states determined by a combination of stochastic and deterministic factors. Bet hedging via seed banking in desert evening primroses Oenothera, Onagraceae : demographic evidence from natural populations. Bet hedging is one solution to the problem of an unpredictably variable environment: fitness in the average environment is sacrificed in favor of lower variation in fitness if this leads to higher long-run stochastic mean fitness.

While bet hedging is an important concept in evolutionary ecology, empirical evidence that it occurs is scant. Here we evaluate whether bet hedging occurs via seed banking in natural populations of two species of desert evening primroses Oenothera, Onagraceae , one annual and one perennial. Four years of data on plants and 3 years of data on seeds yielded two transitions for the entire life cycle. One year was exceptionally dry, leading to reproductive failure in the sample areas, and the other was above average in precipitation, leading to reproductive success in four of five populations.

Stochastic simulations of population growth revealed patterns indicative of bet hedging via seed banking, particularly in the annual populations: variance in fitness and fitness in the average environment were lower with seed banking than without, whereas long-run stochastic mean fitness was higher with seed banking than without across a wide range of probabilities of the wet year. This represents a novel, unusually rigorous demonstration of bet hedging from field data.

Webster, R. We examine, in particular, the impact of basis set size and quality on the prediction of the optical gap and exciton binding energy. The formation of bound excitons by photoexcitation is observed in all the studied systems and this is shown to be correlated to specific features of the Hartree-Fock exchange component of the TD -DFT response kernel. We attribute this reduced exciton binding to the incorrect asymptotics of the B3LYP exchange correlation ground state functional and of the TD -B3LYP response kernel, which lead to a large underestimation of the Coulomb interaction between the excited electron and hole wavefunctions.

Cognitive bias is prevalent among gamblers, especially those with gambling problems. Grounded in the heuristics theories, this study contributes to the literature by examining a cognitive bias triggered by the break streak pattern in the casino setting. We postulate that gamblers tend to bet on the latest outcome when there is a break-streak pattern.

Moreover, three determinants of the betting decision under break-streak pattern, including the streak length of the alternative outcome, the frequency of the latest outcome, and gender, were identified and examined in this study.

A non-participatory observational study was conducted among the Cussec gamblers in a casino in Macao. An analysis of bets confirms our postulation, particularly when the streak of the alternative outcome is long, the latest outcome is frequent, and the gamblers are females. The findings provide meaningful implications for casino management and public policymakers regarding the minimization of gambling harm.

Full Text Available Displacement of Bromodomain and Extra-Terminal BET proteins from chromatin has promise for cancer and inflammatory disease treatments, but roles of BET proteins in metabolic disease remain unexplored.

Small molecule BET inhibitors, such as JQ1, block BET protein binding to acetylated lysines, but lack selectivity within the BET family Brd2, Brd3, Brd4, Brdt, making it difficult to disentangle contributions of each family member to transcriptional and cellular outcomes.

JQ1 increases insulin content in INS-1 cells, accounting for increased secretion, in both rat and human islets. Higher concentrations of JQ1 decrease intracellular triglyceride stores in INS-1 cells, a result of increased fatty acid oxidation. Specific inhibition of both Brd2 and Brd4 enhances insulin transcription, leading to increased insulin content. Inhibition of Brd2 alone increases fatty acid oxidation.

Results imply that cancer and diseases of chronic inflammation or disordered metabolism are related through shared chromatin regulatory mechanisms. Displacement of Bromodomain and Extra-Terminal BET proteins from chromatin has promise for cancer and inflammatory disease treatments, but roles of BET proteins in metabolic disease remain unexplored.

Small molecule BET inhibitors, such as JQ1, block BET protein binding to acetylated lysines, but lack selectivity within the BET family Brd2, Brd3, Brd4, Brdt , making it difficult to disentangle contributions of each family member to transcriptional and cellular outcomes. Genetic variants alter T- bet binding and gene expression in mucosal inflammatory disease. Genome-wide association studies have identified single nucleotide polymorphisms SNPs that may be causative for autoimmune diseases.

The majority of these polymorphisms are located within non-coding distal regulatory elements. It is considered that these genetic variants contribute to disease by altering the binding of regulatory proteins and thus gene expression, but whether these variants alter the binding of lineage-specifying transcription factors has not been determined.

Here, we show that SNPs associated with the mucosal inflammatory diseases Crohn's disease, ulcerative colitis UC and celiac disease, but not rheumatoid arthritis or psoriasis, are enriched at T- bet binding sites. Furthermore, we identify disease-associated variants that alter T- bet binding in vitro and in vivo.

ChIP-seq for T- bet in individuals heterozygous for the celiac disease-associated SNPs rs and rs and the IBD-associated SNPs rs and rs, reveals decreased binding to the minor disease-associated alleles. Furthermore, we show that rs is an expression quantitative trait locus eQTL for the neighboring gene IL18RAP, with decreased T- bet binding associated with decreased expression of this gene.

These results suggest that genetic polymorphisms may predispose individuals to mucosal autoimmune disease through alterations in T- bet binding. Other disease-associated variants may similarly act by modulating the binding of lineage-specifying transcription factors in a tissue-selective and disease-specific manner.

A technique is described where an atmospheric pressure-thermal desorption AP- TD device and electrospray ionization ESI -mass spectrometry are coupled and used for the rapid analysis of Bacillus spores in complex matrices. T- bet -mediated Tim-3 expression dampens monocyte function during chronic hepatitis C virus infection. Hepatitis C virus HCV induces a high rate of chronic infection via dysregulation of host immunity. Importantly, silencing T- bet gene expression decreases Tim-3 expression and enhances interleukin secretion as well as signal transducer and activator of transcription 1 phosphorylation.

These findings reveal a novel mechanism for Tim-3 regulation via T- bet during HCV infection, providing new targets to combat this global epidemic viral disease. Full Text Available The RNA-binding protein L1 TD 1 is one of the most specific and abundant proteins in pluripotent stem cells and is essential for the maintenance of pluripotency in human cells. Here, we identify the protein interaction network of L1 TD 1 in human embryonic stem cells hESCs and provide insights into the interactome network constructed in human pluripotent cells.

L1 TD 1 interacts with multiple stem-cell-specific proteins, many of which are still uncharacterized in the context of development. The pharmacology of TD , a potent and selective 5-HT4 receptor agonist with gastrointestinal prokinetic properties. Full Text Available This study evaluated the in vitro and in vivo pharmacological properties of TD , a potent and selective 5-HT4 receptor agonist. TD had moderate intrinsic activity IA in the in vitro assays.

In conscious guinea pigs, subcutaneous s. Following intraduodenal i. In a single ascending oral dose study in healthy human subjects, TD 0. It is concluded that TD is a potent and selective 5-HT4 receptor agonist in vitro, with robust in vivo stimulatory activity in the gastrointestinal GI tract of guinea pigs, rats, dogs and humans. TD may have clinical utility in patients with disorders of reduced GI motility.

Hybrids between the indica and japonica subspecies of rice Oryza sativa are usually sterile, which hinders utilization of heterosis in the inter-subspecific hybrid breeding. The complex locus Sa comprises two adjacently located genes, Sa F and Sa M, which interact to cause abortion of pollen grains carrying the japonica allele in japonica-indica hybrids. The resultant artificial neutral alleles did not affect pollen viability and other agricultural traits, but did break down the reproductive barrier in the hybrids.

We found that some rice lines have natural neutral allele Sa -n, which was compatible with the typical japonica or indica Sa alleles in hybrids. Our results demonstrate that Sa F and Sa M are required for hybrid male sterility, but are not essential for pollen development.

This study provides effective approaches for the generation of hybrid-compatible lines by knocking out the Sa locus or using the natural Sa -n allele to overcome hybrid male sterility in rice breeding. Bioelectromagnetics published by Wiley Periodicals, Inc. The unknown electric field intensity, electric flux density, and polarization densities representing Kerr nonlinearity along with Lorentz dispersion relation, all of which are induced inside the scatterer upon excitation, are expanded using half and full Schaubert-Wilton-Glisson functions in space.

The TD -EFVIE and the constitutive relations between polarization, field, and flux terms are cast in the form of a first-order ordinary differential equation. The resulting matrix system is integrated in time using a predictor-corrector scheme to obtain the time dependent unknown expansion coefficients. The resulting MOT scheme is explicit and accounts for nonlinearity by simple function evaluations. Due to the mass effect, muonic molecular ions are about times smaller than their electronic counterparts.

The properties of this ion are central to understanding the phenomenon of muon catalysis. The method takes into account both the Coulomb interactions and the strong nuclear forces responsible for the fusion reaction. The wave functions obtained from this method were used to predict very accurately branching ratios and transition rates relevant for various stages of the muon catalytic cycle.

Knowledge of these quantities will guide the experiments and help to answer the question of feasibility of net energy production via muon catalysis. This paper describes the application of generalized equivalence theory to the time-dependent 3-D discrete ordinates neutron transport code TORT- TD. The introduction of pin cell discontinuity factors into the discrete ordinates transport equation is described by assuming a linear dependence of the homogenized neutron angular flux within a pin cell which may be discontinuous at the interfaces to adjacent cells.

The homogenized flux discontinuity at cell interfaces is expressed by pin cell discontinuity factors which in turn are determined from fuel assembly lattice calculations using HELIOS. Oxidation behavior of TD -NiCr in a dynamic high temperature environment. The oxidation behavior of TD -NiCr has been studied in static and high-speed flowing air environments at and C.

It has been found that the stable oxide morphologies formed on the specimens exposed to the static and dynamic environments were markedly different. The faceted crystal morphology characteristic of static oxidation was found to be unstable under high-temperature, high-speed flow conditions and was quickly replaced by a porous NiO 'mushroom' type structure. Also, it was found that the rate of formation of CrO3 from Cr2O3 was greatly enhanced by high gas velocity conditions.

The stability of Cr2-O3 was found to be greatly improved by the presence of an outer NiO layer, even though the NiO layer was very porous. An oxidation model is proposed to explain the observed microstructures and overall oxidation behavior of TD -NiCr alloys. With the commencement of construction of the smart grid, the demand power business for reliability and security continues to improve, the reliability transmission of power TD -LTE Wireless Private Network are more and more attention.

For TD -LTE power private network, it can provide different QoS services according to the user's business type, to protect the reliable transmission of business. This article describes in detail the AF module of PCC in the EPC network, specifically introduces set up AF module station and QoS mechanisms in the EPS load, fully considers the business characteristics of the special power network, establishing a suitable architecture for mapping QoS parameters, ensuring the implementation of each QoS business.

Through using radio bearer management, we can achieve the reliable transmission of each business on physical channel. In the first major part of this chapter, in Sect. In the second major part of this chapter, Sect. In Section 5. This requires identifying promising candidate technologies and advancing them in technology readiness until they are acceptable. Researchers strongly disagree as to what are the best technology project selection methods, or even if there are any proven ones.

Technology development is risky and outstanding achievements are rare and unpredictable. There is no simple formula for success. Organizations that are satisfied with their project selection approach typically use a mix of financial, strategic, and scoring methods in an open, established, explicit, formal process. This approach helps to build consensus and develop management insight. It encourages better project proposals by clarifying the desired project attributes.

We propose a project scoring technique based on a method previously used in a federal laboratory and supported by recent research. Projects are ranked by their perceived relevance, risk, and return - a new 3 R's. Risk is the estimated probability that the project will achieve its specific objective.

Return is the reduction in mission life cycle cost obtained if the project is successful. If the project objective technology performs a new function with no current cost, its return is the estimated cash value of performing the new function. The proposed project selection scoring method includes definitions of the criteria, a project evaluation. For the computational experiments the information from the web sources was used. The authors did not aim to pro- duce a final numerical results, which describe the possible operating conditions.

It was expected only to get accurate qualita- tive results, which can adequately describe the behavior of the airplane IL TD VD when landing on the slippery runway. So, the authors were able to obtain a typical turn of plane at the end of run and show that the pilot style in these conditions has little effect on the qualitative behavior of the aircraft. The most important factor leading to such maneuvers, lies in the special connection of longitudinal and lateral friction of gear wheels with runway.

The results that agree qualitatively with the known situations indicate the possibility for MMS AFD to properly reproduce various cases of aircraft IL TD VD landing to Antarctica ice airfield and identify any inaccurately knownparameters. Live cell imaging of KOPR- td T enables visualization of time course of agonist-induced internalization of KOPR in real time for 60 min, without photobleaching and apparent cell toxicity.

Discussion td T is an alternative to, or even a better tool than, GFPs for fusing to GPCR for trafficking studies, because td T has higher brightness and thus better resolution and less photobleaching problems due to reduced laser power used.

It also has advantages associated with its longer-wavelength emission including spectral separation from autofluorescence and GFPs, reduced cell toxicity the laser may impose, and greater tissue penetration. This work presents the details of mission critical avionics hardware mainly Mission Management Computer MMC and sequencing hardware. Digital autopilot execution in MMC with a periodicity of 10 ms in ascent phase is introduced for the first time and successfully demonstrated in the flight.

SPS is designed as a high reliability system by incorporating various fault tolerance and fault detection features. CEM is a relay based module for sequence command execution. The ban of animal testing has enhanced the development of new in vitro technologies for cosmetics safety assessment. Impedance metrics is one such technology which enables monitoring of cell viability in real time.

However, analyzing real time data requires moving from static to dynamic toxicity assessment. These models account for the fate of the tested compounds during the assay. Only for one out of the three compounds, the models calibrated with a single exposure were able to predict repeated exposure data. We therefore recommend the use of long-term exposure in vitro data in order to adequately account for chronic hepatotoxic effects.

The models we propose here are capable of being coupled with human biokinetic models in order to relate dose exposure and human hepatotoxicity. Published by Elsevier Ireland Ltd.. Project BET Business and Education Together was initiated by the California Chamber of Commerce in January to assist local chambers of commerce in developing long-term school-business partnerships. This handbook, based on work with six pilot chambers of commerce, offers a step-by-step process guide to school-business partnerships, along….

Soccer clubs listed on the London Stock Exchange provide a unique way of testing stock price reactions to different types of news. For each firm, two pieces of information are released on a weekly basis: experts' expectations about game outcomes through the betting odds, and the game outcomes. Information salience, investor sentiment and stock returns : The case of British soccer betting.

India had a very active maritime trade contact with the Roman world between the 4th century BC and the 4th century AD. In this context recent finds of stone anchors, potsherds, lead anchors and a lead ingot from 5 to 8 m water-depth near Bet Dwarka The authors argue that the recent increase in poker play among adolescent males in the United States was primarily attributable to high-status male youth who are more able to organize "informal" gambling games e.

Responsiveness of the major birch allergen Bet v 1 scaffold to the gastric environment: Impact on structure and allergenic activity. Four Bet v 1 homologous food allergens from celeriac rApi g 1 , apple rMal d 1 , peach rPru p 1 and hazelnut rCor a 1 , were used to probe the structural responsiveness of the Bet v 1 scaffold to gastric digestion conditions and its impact on allergenicity This result suggests that an effective method for BET etching is chemically assisted physical etching.

With increasing coil RF power, the plasma density increases so that the increased reactive free radicals and ions enhance the etch rates of BET , Pt, and SiO 2. As the dc-bias voltage is increased, the increased ion energy leads to an increased etch rate of BET films. These results seem to indicate that Bi and Eu react little with Cl atoms and are removed predominantly by argon-ion bombardment.

Also, Ti reacts little with Cl radicals and is mainly removed by chemically assisted physical etching. The impact of near-miss events on betting behavior: An examination of casino rapid roulette play. Full Text Available We examine how almost winning in roulette affects subsequent betting behavior. Our main finding is heterogeneity in gambler behavior with some gamblers less likely to bet on numbers that were near misses on the prior spin and other gamblers more likely to bet on near miss numbers.

Using a unique data set from the game rapid roulette, we model the likelihood of a gambler betting on a near miss number while controlling for the favorite number bias and the likelihood of a number being a near miss. We also find no evidence that near misses in roulette leads to gamblers extending the time spent gambling or to the placing of more bets.

Molecular dynamics of formation of TD lesioned DNA complexed with repair enzyme - onset of the enzymatic repair process. Tokai Research Establishment. Arsenal ARS. Leeds LEE. Brighton BRI. Aston Villa AST. Chelsea CHE. Newcastle NEW. Palace CRY. Burnley BUR. Everton EVE.

Leicester LEI. Liverpool LIV. Man City MC. Tottenham TOT. West Bromw. Man United MU. West Ham WHA. Sheffield U. The three most likely results. KickForm score recommendations for your tip game. Premier League. Champion Prognosis. Champions League Prognosis. Relegation Prognosis. Current football predictions and tips KickForm. Football predictions and betting recommendations. FC Arsenal. Leeds United. Score Prediction KickForm :.

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